Seahorse Laboratories Ltd
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Non-invasive breath tests can serve as valuable diagnostic tools in medicine as they can determine particular enzymatic and metabolic functions in vivo. This has wide applications in the fields of gastroenterology, oncology, hepatology and nutrition control. A 13CO2 breath test measures increased levels of 13CO2 in exhaled breath after ingestion of a stable 13C isotope labelled substance and its subsequent metabolism with a specific function or enzyme as a rate limiting step. Breath samples are collected and analysed, for example, with a Kibion® infrared instrument, measuring the time between ingestion by the patient of the labelled substance and its appearance in the exhaled breath.
In the UK, the most common 13C substrates (except for 13C Urea, available commercially as Diabact) are available directly from Seahorse Laboratories as specials1:

SubstrateMetabolic Indication
13C MethacetinLiver function
13C Sodium AcetateGastric emptying (liquid)
13C Octanoic AcidGastric emptying (solid)
13C Mixed TriglyceridePancreatic function

1Unlicensed medicinal products for human use (commonly described as “specials”) which have been specially manufactured or imported to the order of a doctor, dentist, nurse independent prescriber, pharmacist independent prescriber or supplementary prescriber for the treatment of individual patients.

Please see our application brochure for a literature review of these and other forthcoming substrates used for 13C breath testing

For further information please
contact us

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